Cardiogen

Cardiogen is the synthetic Ala-Glu-Asp-Arg tetrapeptide described in rat myocardial explant and organotypic culture studies.

Identity

Sequence

H-AEDR-OH

Residues

4

Molecular formula

C₁₈H₃₁N₇O₉

Average molecular weight

489.5 g/mol

Monoisotopic mass (calculated)

489.2183 Da

CAS number

Not recorded

PubChem CID

11583989

Other names

AEDR

The free AEDR structure is verified; the Cardiogen name is linked to AEDR in a published review. A same-name carnitine record was rejected. CAS was not verified. Literature is limited and mainly from one group; UniProt is inapplicable and SMILES and 2D coordinates were not transcribed.

Identity data from: PubChem CID 11583989: properties, biologic line notation and synonyms · PubMed PMID 34834147, Table 5: Cardiogen corresponds to AEDR

Research overview

Cardiogen is a defined synthetic tetrapeptide with the sequence Ala-Glu-Asp-Arg, or AEDR. Alanine precedes the Glu-Asp pair, and arginine forms the last residue. Its sequence-based identity should be distinguished from unrelated substances that share the name in database synonyms. The primary articles describe the material as a tetrapeptide and examine it with isolated tissue cultures. These experiments address cellular behaviour within explants rather than assigning the peptide to a validated receptor [1][2].

One study compared Cardiogen with individual amino acids in organotypic myocardial cultures obtained from rats of different ages. Proliferation and apoptosis-related measurements were considered together, including immunohistochemical detection of p53. The authors reported a change in p53 staining and differences in the explant responses; staining alone does not fully resolve the sequence of intracellular events or show a direct molecular target [1]. An earlier study included heart, lung, prostate and pancreatic explants from rats and compared Cardiogen, Bronchogen, Prostamax and Pancragen. This provides a tissue-culture comparison within the investigators’ model design. An explant retains local tissue interactions, but its observations are distinct from cardiac physiology in a living animal [2].

The cited biological literature is limited and mainly comes from one connected research group. These experiments describe particular cell or tissue systems. Their readouts do not establish a general mechanism across organs, and independent replication remains important when assessing the proposed molecular interactions [1][2].

Laboratory storage and handling

Follow the storage conditions stated in the documentation supplied with the lot. Keep the sealed vial cold, dry and protected from light. Let it reach room temperature before opening to reduce moisture condensation on the material. Avoid repeated freezing and thawing of laboratory stocks, record lot identifiers with experiments and wear standard laboratory protective equipment. Published biological observations do not establish storage stability for a particular lot.

Questions about Cardiogen

References

1. [The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats]. Adv Gerontol 2009. PMID 20210190
2. [The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats]. Adv Gerontol 2006. PMID 17152728

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.