Kisspeptin-10

Kisspeptin-10 is an amidated KISS1-derived decapeptide examined in GPR54 signalling and GnRH neuron calcium studies.

Identity

Sequence

H-YNWNSFGLRF-NH2

Residues

10

Molecular formula

C₆₃H₈₃N₁₇O₁₄

Average molecular weight

1302.4 g/mol

Monoisotopic mass (calculated)

1301.6305 Da

CAS number

374675-21-5

PubChem CID

25240297

Strengths

5–10 mg

Other names

KP-10

The profile describes the free, unphosphorylated amidated peptide from KISS1 positions 112–121. Q15726 identifies the parent precursor; its annotated phosphotyrosine is excluded from this peptide representation. A residue diagram replaces SMILES and atomic coordinates, and blend components do not apply.

Identity data from: PubChem CID 25240297 · UniProt Q15726, KISS1 precursor and Kisspeptin-10 feature 112–121

Research overview

Kisspeptin-10 is a ten-residue peptide corresponding to positions 112–121 of the KISS1 precursor, with an amidated C-terminal phenylalanine. The suffix identifies the length of this fragment rather than its position in the precursor. The cited studies examine kisspeptin signalling through GPR54 in GnRH neurons, placing the peptide in a defined neuroendocrine research context [1][2].

One study maintained GnRH-1 neurons in mouse nasal explants and monitored intracellular calcium. It examined spontaneous oscillations and their relationship to membrane channel activity, then investigated how kisspeptin-10 engagement of GPR54 changed those signals. The experiments considered phospholipase C signalling, inositol trisphosphate and protein kinase C, alongside membrane sodium channels. These measurements concern the calcium oscillator in the neuronal preparation and distinguish membrane-driven activity from calcium release out of intracellular stores [1].

A separate electrophysiological study investigated the currents associated with kisspeptin-induced depolarization of GnRH neurons. It examined nonselective cation channels with TRPC-like properties and inwardly rectifying potassium channels, and used single-cell RNA analysis to examine TRPC subunits. The calcium and electrical studies offer complementary views of neuronal signalling. Neither a current trace nor a calcium signal alone identifies every intermediate in the pathway, so the measured channel and messenger context remains important when comparing experimental systems [2].

Laboratory storage and handling

Store sealed peptide vials under the temperature conditions stated in the lot documentation, protected from light and moisture. Let a cold vial reach room temperature before opening to limit condensation. Avoid repeated freezing and thawing of laboratory stocks, record storage history and the lot identifier, and use standard laboratory protective equipment. Chemical modifications and counterions should be checked against the supplied analytical description.

Questions about Kisspeptin-10

References

1. Kisspeptin-10 facilitates a plasma membrane-driven calcium oscillator in gonadotropin-releasing hormone-1 neurons. Endocrinology 2009. PMID 18948403
2. Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels. J Neurosci 2008. PMID 18434521

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.