Pinealon

Pinealon is a synthetic Glu-Asp-Arg tripeptide examined in cell-based oxidative-stress and nucleic-acid interaction models.

Identity

Sequence

H-EDR-OH

Residues

3

Molecular formula

C₁₅H₂₆N₆O₈

Average molecular weight

418.4 g/mol

Monoisotopic mass (calculated)

418.1812 Da

CAS number

175175-23-2

PubChem CID

10273502

Strengths

5–20 mg

Other names

EDR

Identity values describe the free peptide; the separately recorded acetate has a different formula and mass. The cited literature is limited and mainly from one connected group. UniProt does not apply, and SMILES and 2D coordinates were not transcribed.

Identity data from: PubChem CID 10273502: properties, biologic line notation and synonyms

Research overview

Pinealon contains three residues, Glu-Asp-Arg, in that order. Its two acidic residues precede a terminal arginine, and the verified identity describes the unmodified free peptide rather than its acetate. The compound appears in short-peptide research under its name and sequence. One primary study identifies the synthetic tripeptide explicitly and places it in experiments on cellular oxidative stress, rather than establishing a receptor-selective ligand [1].

That study used cerebellar granule cells, neutrophils and PC12 cells, with measurements of reactive oxygen species, propidium-iodide staining, ERK1/2 activation and cell-cycle distribution. The authors reported changes in those readouts under their experimental conditions; the combination of assays addresses cellular responses and does not by itself identify direct genome binding [1]. A separate investigation used fluorescently labelled Pinealon in HeLa cells and compared fluorescence quenching with labelled oligonucleotides and DNA complexes. Nuclear fluorescence and sequence-dependent quenching were reported, providing an experimental basis for discussing peptide–nucleic-acid interactions while keeping labelled-cell observations distinct from measurements made with intact peptides [2].

The cited biological literature is limited and mainly comes from one connected research group. These experiments describe particular cell or tissue systems. Their readouts do not establish a general mechanism across organs, and independent replication remains important when assessing the proposed molecular interactions [1][2].

Laboratory storage and handling

Follow the storage conditions stated in the documentation supplied with the lot. Keep the sealed vial cold, dry and protected from light. Let it reach room temperature before opening to reduce moisture condensation on the material. Avoid repeated freezing and thawing of laboratory stocks, record lot identifiers with experiments and wear standard laboratory protective equipment. Published biological observations do not establish storage stability for a particular lot.

Questions about Pinealon

References

1. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res 2011. PMID 21978084
2. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc) 2011. PMID 22117547

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.