AOD

AOD-9604 is a synthetic 16-residue analogue of the C-terminal region of human growth hormone, with an N-terminal tyrosine.

Identity

Sequence

H-YLRIVQCRSVEGSCGF-OH

Residues

16

Bridges and complexes

Cys7–Cys14 (S–S)

Molecular formula

C₇₈H₁₂₃N₂₃O₂₃S₂

Average molecular weight

1815.1 g/mol

Monoisotopic mass (calculated)

1813.8604 Da

CAS number

221231-10-3

PubChem CID

71300630

Strengths

5–10 mg

Other names

AOD9604 · AOD 9604

Identity values describe the free peptide with its disulfide bridge. An acetate name also occurs in PubChem, and 386264-39-7 is marked as a deprecated CAS. No separate UniProt identity was verified; the sequence represents the structure instead of atom coordinates or SMILES. This is a single peptide, without blend components.

Identity data from: PubChem CID 71300630

Research overview

AOD-9604 consists of the C-terminal hGH 177-191 sequence with a tyrosine added at the N terminus. Its 16 residues are YLRIVQCRSVEGSCGF, and the identity record includes a disulfide bridge between Cys7 and Cys14. The analytical literature describes this molecular identity explicitly, providing a basis for distinguishing the analogue from the native 176-191 fragment [1].

One study examined how AOD-9604 could be recognised analytically and which peptide fragments appeared during incubation in serum and urine. The researchers characterised six potential metabolites and identified CRSVEGSCG as a comparatively persistent fragment in serum. The work concerns measurement of the parent peptide and its breakdown products in biological matrices; it does not establish that a fragment is interchangeable with the original molecule [1].

A separate publication examined AOD-9604, hyaluronic acid and their combination in a collagenase-induced knee model in New Zealand white rabbits. Its assessments included joint morphology, histopathological scoring and observation of movement. This paper supplies an animal-model context distinct from the analytical study. The model, accompanying material and endpoints belong to that experiment, and are not properties demonstrated for every sample bearing the AOD-9604 name [2].

Laboratory storage and handling

Store sealed peptide vials under the temperature conditions stated in the lot documentation, protected from light and moisture. Let a cold vial reach room temperature before opening to limit condensation. Avoid repeated freezing and thawing of laboratory stocks, record storage history and the lot identifier, and use standard laboratory protective equipment. Chemical modifications and counterions should be checked against the supplied analytical description.

Questions about AOD-9604

References

1. Detection and in vitro metabolism of AOD9604. Drug Test Anal 2015. PMID 25208511
2. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci 2015. PMID 26275694

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.