ARA-290

ARA-290 is an 11-residue erythropoietin-derived helix-B surface peptide with an N-terminal pyroglutamate residue.

Identity

Sequence

H-[pGlu]EQLERALNSS-OH

Residues

11

Molecular formula

C₅₁H₈₄N₁₆O₂₁

Average molecular weight

1257.3 g/mol

Monoisotopic mass (calculated)

1256.5997 Da

CAS number

1208243-50-8

PubChem CID

91810664

Other names

Cibinetide · pHBSP

pGlu means N-terminal pyroglutamate; the remaining ten residues are EQLERALNSS. The formula describes the free peptide, without a counterion. No fragment-specific UniProt entry or intact SMILES representation was verified.

Identity data from: PubChem CID 91810664

Research overview

ARA-290, also called cibinetide or pHBSP, is an 11-residue peptide designed from the exposed surface of erythropoietin helix B. Its sequence starts with pyroglutamate rather than an ordinary linear glutamate residue. The cited review explains the structural design and discusses a proposed receptor complex involving the erythropoietin receptor and the beta-common receptor subunit. This is a distinct experimental framework from simply regarding the short peptide as an abbreviated version of the complete erythropoietin protein. The review assembles studies of cellular stress responses and receptor-associated signaling, providing context for why a selected surface sequence was investigated [1].

A primary study examined ARA-290 in pristane-induced and MRL/lpr mouse models of systemic lupus erythematosus, together with macrophage experiments in vitro. The investigators measured circulating inflammatory markers, antibody-related measurements and kidney-associated cellular observations. The cell experiments separately examined inflammatory activation of macrophages and their interactions with apoptotic cells. These are named model systems with their own readouts and experimental controls. They describe how the peptide was studied, without establishing that a change in one laboratory marker predicts a general outcome in another setting. The molecular identity and the boundaries of each cited experiment therefore need to be retained together [2].

Laboratory storage and handling

Keep the sealed vial cold, dry and protected from light, following the conditions in the documentation supplied with the lot. Let the vial reach room temperature before opening to limit moisture condensation. Avoid repeated freezing and thawing of laboratory stocks. Record the lot identifier and the material form with each experiment, and use standard laboratory protective equipment.

Questions about ARA-290

References

1. Flipping the molecular switch for innate protection and repair of tissues: Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin. Pharmacol Ther 2015. PMID 25728128
2. Non-erythropoietic erythropoietin-derived peptide protects mice from systemic lupus erythematosus. J Cell Mol Med 2018. PMID 29570934

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.