DSIP

DSIP is a nine-residue peptide first isolated from rabbit cerebral venous blood; its biological identity and role remain unresolved.

Identity

Sequence

H-WAGGDASGE-OH

Residues

9

Molecular formula

C₃₅H₄₈N₁₀O₁₅

Average molecular weight

848.8 g/mol

Monoisotopic mass (calculated)

848.3301 Da

CAS number

62568-57-4

PubChem CID

68816

Strengths

5–15 mg

Other names

Delta sleep-inducing peptide · Emideltide

Identity data from: PubChem CID 68816

Research overview

DSIP is the abbreviation for delta sleep-inducing peptide, a name arising from its isolation history. A later review traces its isolation to rabbit cerebral venous blood and emphasises that its natural occurrence and biological role remain unclear [1]. The recorded molecule is a linear nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, a free amino terminus and a free carboxyl terminus.

An earlier review describes DSIP-like material detected by radioimmunoassay and immunohistochemistry in brain samples, and by radioimmunoassay in rat peripheral organs and mammalian plasma [2]. The later review questions whether DSIP-like immunoreactivity necessarily identifies the same molecular entity, and proposes related peptides as a possibility. It also notes the absence of an isolated gene or protein that would clarify the peptide's origin. Histochemical studies discussed in the review locate DSIP-like immunoreactivity in neurosecretory hypothalamic nuclei of several vertebrate species [1].

A subsequent experiment examined DSIP in Sprague–Dawley rats after focal cerebral ischaemia produced by middle cerebral artery occlusion. Researchers assessed motor coordination and balance and measured infarct volume. The reported difference in infarct volume was not statistically significant, while recovery in a rotarod measurement differed between groups [3]. The study included sham-operated, DSIP and vehicle comparison groups, assessed bilateral asymmetry, and calculated infarct volume from serial brain cryosections [3].

Laboratory storage and handling

Keep the peptide in a sealed vial under the storage conditions specified for its lot, protected from moisture and light. Allow the vial to reach room temperature before opening to limit condensation on the solid. Avoid repeated freezing and thawing of laboratory stocks, and retain the lot identifier and storage record with experimental notes. Wear standard laboratory protective equipment and follow the accompanying material documentation.

Questions about DSIP

References

1. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem 2006. PMID 16539679
2. Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev 1984. PMID 6145137
3. Delta Sleep-Inducing Peptide Recovers Motor Function in SD Rats after Focal Stroke. Molecules 2021. PMID 34500605

Identity data checked on 2026-09-24. Literature summaries describe published research models and are not specifications of any product lot.