Gonadorelin

Gonadorelin is the amidated GnRH decapeptide with an N-terminal pyroglutamate, studied in pituitary receptor signalling.

Identity

Sequence

H-[pGlu]HWSYGLRPG-NH2

Residues

10

Molecular formula

C₅₅H₇₅N₁₇O₁₃

Average molecular weight

1182.3 g/mol

Monoisotopic mass (calculated)

1181.5730 Da

CAS number

33515-09-2

PubChem CID

638793

Other names

GnRH · Gonadotropin-releasing hormone

The identity values describe the free peptide. PubChem also lists CAS 9034-40-6; this profile uses 33515-09-2 and excludes the related hydrochloride and acetate salts. pGlu means pyroglutamate. No separate UniProt accession was verified; a residue diagram replaces SMILES and atomic coordinates, and blend components do not apply.

Identity data from: PubChem CID 638793

Research overview

Gonadorelin is the synthetic counterpart of gonadotropin-releasing hormone, commonly abbreviated GnRH. It is a ten-residue peptide with an N-terminal pyroglutamate and a C-terminal amide. These terminal groups form part of its molecular identity rather than optional additions to the sequence. The cited reviews place this ligand in studies of a membrane receptor on pituitary gonadotrophs and the intracellular signals that follow receptor engagement [1][2].

An early review describes phosphoinositide hydrolysis, phospholipase C activation and the formation of inositol trisphosphate and diacylglycerol. It discusses calcium release from intracellular stores alongside calcium entry through membrane channels. Those processes provide distinct experimental measurements: receptor binding, messenger generation and calcium dynamics address different stages of a signalling pathway. The account also identifies questions that remained unresolved, including the relative roles of the different messengers [1].

A later review examines how calcium and protein kinase C pathways interact in GnRH receptor signalling. It considers phospholipases, lipid-derived messengers and the MAPK cascade, together with transcriptional readouts such as c-fos and c-jun. The models concern gonadotroph signalling rather than an isolated peptide acting independently of its receptor. Reading the two accounts together helps distinguish molecular identity from the cell-specific pathway measurements used to investigate it; their pathway descriptions should retain the experimental context [2].

Laboratory storage and handling

Store sealed peptide vials under the temperature conditions stated in the lot documentation, protected from light and moisture. Let a cold vial reach room temperature before opening to limit condensation. Avoid repeated freezing and thawing of laboratory stocks, record storage history and the lot identifier, and use standard laboratory protective equipment. Chemical modifications and counterions should be checked against the supplied analytical description.

Questions about Gonadorelin

References

1. Signal transduction mechanisms of Ca2+ mobilizing hormones: the case of gonadotropin-releasing hormone. Endocr Rev 1990. PMID 2194785
2. Mechanism of GnRH receptor signaling: combinatorial cross-talk of Ca2+ and protein kinase C. Front Neuroendocrinol 1998. PMID 9465287

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.