Prostamax

Prostamax is a synthetic Lys-Glu-Asp-Pro tetrapeptide examined in cultured-cell chromosome and heterochromatin studies.

Identity

Sequence

H-KEDP-OH

Residues

4

Molecular formula

C₂₀H₃₃N₅O₉

Average molecular weight

487.5 g/mol

Monoisotopic mass (calculated)

487.2278 Da

CAS number

473578-47-1

PubChem CID

9848296

Other names

KEDP

The identity describes the free KEDP peptide. The cited literature is limited and mainly from one connected research group. UniProt does not apply; SMILES and 2D coordinates were not transcribed because the residue diagram is used.

Identity data from: PubChem CID 9848296: properties, biologic line notation and synonyms

Research overview

Prostamax is Lys-Glu-Asp-Pro, or KEDP, a four-residue synthetic peptide. The sequence begins with lysine and ends with proline, with glutamate and aspartate between them. The opened identity record describes the free peptide and its unmodified termini. A primary article places the complete sequence in its title and identifies the tested material as Prostamax in the abstract. This establishes which short peptide the chromatin experiments address, without assigning a tissue-specific receptor from its name [1].

The sequence-titled study examined cultured cells from older donors. It evaluated sister-chromatid exchanges, silver-positive nucleolus-organizer regions and structural pericentromeric heterochromatin. The authors reported changes in those chromosome-associated parameters, interpreting them in relation to chromatin decondensation. These measurements describe chromosome organisation and exchange events in that culture system; they do not establish the consequences of the changes across other cell types [1]. Another paper compared Prostamax with Vilon, Epithalon, Livagen and Cortagen in cultured leukocytes. It considered ribosomal-gene activity, chromatin melting characteristics and chromosome-specific heterochromatin variability. Findings from a multi-peptide comparison require attention to which peptide and assay were involved, rather than treating all reported chromatin changes as a single verified molecular mechanism [2].

The cited biological literature is limited and mainly comes from one connected research group. These experiments describe particular cell or tissue systems. Their readouts do not establish a general mechanism across organs, and independent replication remains important when assessing the proposed molecular interactions [1][2].

Laboratory storage and handling

Follow the storage conditions stated in the documentation supplied with the lot. Keep the sealed vial cold, dry and protected from light. Let it reach room temperature before opening to reduce moisture condensation on the material. Avoid repeated freezing and thawing of laboratory stocks, record lot identifiers with experiments and wear standard laboratory protective equipment. Published biological observations do not establish storage stability for a particular lot.

Questions about Prostamax

References

1. [Deheterochromatinization of the chromatin in old age induced by oligopeptide bioregulator (Lys-Glu-Asp-Pro)]. Georgian Med News 2012. PMID 23221144
2. Effects of short peptides on lymphocyte chromatin in senile subjects. Bull Exp Biol Med 2004. PMID 15085253

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.