Adipotide

Adipotide is a peptide conjugate described with a cyclic CKGGRAKDC targeting motif, a GG linker and a D-amino-acid segment.

Research overview

Adipotide is described in the cited literature as a ligand-directed peptide conjugate. The published structural description combines a cyclic CKGGRAKDC targeting motif, a GG linker and a D(KLAKLAK)2 segment. These elements have different roles in the experimental design: one supplies a recognition motif and the other is the attached D-peptide segment. This textual architecture does not resolve every terminal group or the precise ring-closure chemistry, and it should not be substituted for a verified full chemical structure [2].

The earlier mouse study used in vivo phage display to identify CKGGRAKDC and examined its association with prohibitin, a membrane-associated protein. It placed the motif in vascular-targeting experiments rather than identifying a conventional receptor agonist. The later study examined the conjugated material in Old World monkeys and included vascular tissue observations. The species, targeting method and histological context define those investigations; this profile confines its discussion to the molecular targeting question and the named models [1][2].

The opened database candidate describes a linear peptide, which conflicts with the cyclic motif in the paper. Its formula and identifiers therefore cannot authenticate the cyclic conjugate. The cited literature is limited and largely comes from the same originating research network. Structural uncertainty and the limited independence of these studies should remain explicit when comparing experimental materials [1][2].

Laboratory storage and handling

Follow the storage conditions stated in the documentation supplied with the lot. Keep the sealed vial cold, dry and protected from light. Let it reach room temperature before opening to reduce moisture condensation on the material. Avoid repeated freezing and thawing of laboratory stocks, record lot identifiers with experiments and wear standard laboratory protective equipment. Published biological observations do not establish storage stability for a particular lot.

Questions about Adipotide

References

1. Reversal of obesity by targeted ablation of adipose tissue. Nat Med 2004. PMID 15133506
2. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med 2011. PMID 22072637

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.