GHRP-2

GHRP-2, also called pralmorelin, is a synthetic amidated hexapeptide containing D-amino acids and D-2-naphthylalanine.

Identity

Sequence

H-[D-Ala][D-2Nal]AW[D-Phe]K-NH2

Residues

6

Molecular formula

C₄₅H₅₅N₉O₆

Average molecular weight

818 g/mol

Monoisotopic mass (calculated)

817.4275 Da

CAS number

158861-67-7

PubChem CID

6918245

Strengths

5–10 mg

Other names

Pralmorelin · KP-102

D-2Nal means D-2-naphthylalanine; D-Ala and D-Phe indicate D-amino acids. Values refer to the free amidated peptide. PubChem marks 908593-10-2 as a deprecated CAS. No separate UniProt identity was verified; the residue sequence represents the structure without atom coordinates or SMILES. Blend components do not apply.

Identity data from: PubChem CID 6918245

Research overview

GHRP-2 is the synthetic hexapeptide also indexed as pralmorelin. Its sequence is D-Ala-D-2Nal-Ala-Trp-D-Phe-Lys-NH2: three positions contain D-amino acids, including the nonstandard aromatic residue D-2-naphthylalanine, and the C terminus is amidated. The compound has been compared with the structurally distinct GHRP-6 in pituitary-cell experiments, which examine receptor-linked secretion rather than the properties of the full-length hypothalamic peptide GHRH [1].

In primary rat pituitary cells, investigators compared GHRP-2 with GHRP-6 and used antagonist and desensitisation experiments to examine whether their signals shared a receptor system. The cells showed reciprocal desensitisation to the two peptides, while the response to GRF remained distinguishable. A peptide antagonist inhibited the GHRP-2 response, whereas a GRF antagonist did not. Those observations supported a common pathway for the two short peptides in that rat-cell preparation [1].

A second study used cultured human pituitary somatotropinoma cells with or without activating gsp oncogenes. It measured phosphatidylinositol hydrolysis and cAMP and examined protein kinase C and calmodulin contributions. The authors observed that cAMP responses depended on the cellular signalling background and discussed communication between phosphoinositide and adenylyl cyclase systems. This cell-culture work concerns defined tissue and genotype contexts, so a signalling observation should remain attached to the experimental system in which it was measured [2].

Laboratory storage and handling

Store sealed peptide vials under the temperature conditions stated in the lot documentation, protected from light and moisture. Let a cold vial reach room temperature before opening to limit condensation. Avoid repeated freezing and thawing of laboratory stocks, record storage history and the lot identifier, and use standard laboratory protective equipment. Chemical modifications and counterions should be checked against the supplied analytical description.

Questions about GHRP-2

References

1. Growth hormone releasing peptides: a comparison of the growth hormone releasing activities of GHRP-2 and GHRP-6 in rat primary pituitary cells. Life Sci 1997. PMID 9096259
2. Protein kinase C-dependent growth hormone releasing peptides stimulate cyclic adenosine 3',5'-monophosphate production by human pituitary somatotropinomas expressing gsp oncogenes: evidence for crosstalk between transduction pathways. Mol Endocrinol 1996. PMID 8721987

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.