Vesugen

Vesugen is the synthetic Lys-Glu-Asp tripeptide studied in fibroblast cultures for protein-expression and differentiation markers.

Identity

Sequence

H-KED-OH

Residues

3

Molecular formula

C₁₅H₂₆N₄O₈

Average molecular weight

390.39 g/mol

Monoisotopic mass (calculated)

390.1751 Da

CAS number

204271-66-9

PubChem CID

87571363

Other names

KED

The free KED structure is recorded as lysyl-glutamyl-aspartic acid; the paper explicitly links that sequence to Vesugen. Literature is limited and mainly from one connected group. UniProt does not apply, and SMILES and 2D coordinates were not transcribed.

Identity data from: PubChem CID 87571363: properties, biologic line notation and synonyms · PubMed 22808515: Vesugen named for the Lys-Glu-Asp sequence

Research overview

Vesugen is identified in the cited fibroblast study as Lys-Glu-Asp, or KED. Lysine occupies its first position, followed by glutamate and aspartate; the free-peptide structure has no additional residue or terminal cap. This identity matters because several peptides were compared in the same experiments. The name should therefore remain linked to KED rather than to a general extract or to every peptide mentioned alongside it [1].

The first paper examined cultures of human prostatic fibroblasts alongside pancreatic and bronchial cell cultures. For the fibroblast arm, investigators measured differentiation-associated CXCL12 and WEGC1 expression and compared cultures at different passages. They reported changes in marker expression associated with Vesugen in that defined culture system [1]. Another paper investigated KED together with KE, AED and AEDG in skin fibroblasts, using immunofluorescent confocal microscopy to examine Ki-67, CD98hc, caspase-3 and MMP-9. The assays describe protein-expression patterns in cultured cells; they do not demonstrate a direct DNA-binding event, a unique receptor, or a physiological vascular response in a whole organism [2].

The cited biological literature is limited and mainly comes from one connected research group. These experiments describe particular cell or tissue systems. Their readouts do not establish a general mechanism across organs, and independent replication remains important when assessing the proposed molecular interactions [1][2].

Laboratory storage and handling

Follow the storage conditions stated in the documentation supplied with the lot. Keep the sealed vial cold, dry and protected from light. Let it reach room temperature before opening to reduce moisture condensation on the material. Avoid repeated freezing and thawing of laboratory stocks, record lot identifiers with experiments and wear standard laboratory protective equipment. Published biological observations do not establish storage stability for a particular lot.

Questions about Vesugen

References

1. Peptides tissue-specifically stimulate cell differentiation during their aging. Bull Exp Biol Med 2012. PMID 22808515
2. Peptide Regulation of Skin Fibroblast Functions during Their Aging In Vitro. Bull Exp Biol Med 2016. PMID 27259496

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.