VIP5

VIP is an amidated 28-residue peptide processed from a larger precursor and studied as a ligand of VPAC receptors.

Identity

Sequence

H-HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2

Residues

28

Molecular formula

C₁₄₇H₂₃₈N₄₄O₄₂S

Average molecular weight

3325.847 g/mol

Monoisotopic mass (calculated)

3323.7561 Da

CAS number

Not recorded

Strengths

5–10 mg

Other names

Vasoactive intestinal peptide

The sequence follows the amidated peptide in UniProt P01282. Opened PubChem name records described the free-acid form, so their CID and CAS were not assigned here. Formula and average weight were computed from the sourced sequence. SMILES was not verified.

Identity data from: UniProtKB P01282 · computed from the sequence

Research overview

VIP is vasoactive intestinal peptide, a 28-residue peptide whose C-terminal asparagine is amidated. UniProt identifies it within a larger precursor that also contains other processed peptides. Receptor research describes VIP recognition by VPAC1 and VPAC2, members of the class B G-protein-coupled receptor family. The first cited review examines how the extracellular receptor domain contributes to ligand binding and how receptor activation connects to adenylyl cyclase. It brings together site-directed mutagenesis, photoaffinity labeling, nuclear magnetic resonance and molecular modeling. These methods address different aspects of the interaction between a peptide ligand and the receptor that recognizes it [1].

A subsequent structural study determined active receptor complexes by cryo-electron microscopy, including a VIP–VPAC1 receptor complex associated with Gs. Comparison with PACAP-containing complexes and molecular-dynamics analyses examined ligand binding and receptor selectivity. The resulting structures describe the arrangements captured in those experimental complexes, while simulations explore possible motions around them. This combination supplies a molecular framework for comparing related peptide–receptor systems. It does not mean that all members of the receptor family recognize each ligand in exactly the same way, or that precursor peptides and mature amidated VIP have identical molecular identities [2].

Laboratory storage and handling

Keep the sealed vial cold, dry and protected from light, following the conditions in the documentation supplied with the lot. Let the vial reach room temperature before opening to limit moisture condensation. Avoid repeated freezing and thawing of laboratory stocks. Record the lot identifier and the material form with each experiment, and use standard laboratory protective equipment.

Questions about VIP

References

1. VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins. Br J Pharmacol 2012. PMID 21951273
2. Understanding VPAC receptor family peptide binding and selectivity. Nat Commun 2022. PMID 36385145

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.