5-Amino-1MQ

5-Amino-1MQ is a methylated quinolinium cation examined as a small-molecule inhibitor of nicotinamide N-methyltransferase.

Identity

Molecular formula

C₁₀H₁₁N₂⁺

Average molecular weight

159.21 g/mol

Monoisotopic mass (calculated)

159.0917 Da

CAS number

685079-15-6

PubChem CID

950107

Strengths

5–50 mg

Other names

5-Amino-1-methylquinolinium

The formula and molecular weight describe the 5-amino-1-methylquinolinium cation. The product information does not specify the counter-ion present in the supplied material.

Identity data from: PubChem CID 950107

Research overview

5-Amino-1MQ denotes 5-amino-1-methylquinolinium, a positively charged small molecule with a methyl group on the ring nitrogen and an amino group at position 5. Its formula and molecular weight describe the cation; the product information does not specify a counter-ion. The cited research examines it as an inhibitor of nicotinamide N-methyltransferase, abbreviated NNMT. The cell-culture paper uses the abbreviation 5MQ and examines HeLa cervical epithelial cancer cells, with HEK-293 cells for comparison. Cell viability was assessed with an MTT assay, while quantitative real-time polymerase chain reaction and Western blotting were used for messenger RNA and protein measurements [1].

The HeLa study also examined cell morphology and included TWIST, ZEB1, SERPIN1, SIRT1 and CD16 among its messenger RNA measurements. The protein analyses included phospho-Akt and SIRT1 [1]. A separate mouse study examined cecal microbiomes in animals with diet-induced obesity after a switch from a high-fat Western diet to a low-fat diet, with or without NNMT inhibition. Its comparison groups included age-matched lean animals and mice maintained on the Western diet. The analysis considered microbial alpha diversity and used principal coordinates analysis to examine beta diversity. Researchers also applied K-means clustering to amplicon sequence variants from individual animals and examined associations between microbial relative abundances and adipose-tissue metabolites [2].

Laboratory storage and handling

Store the closed vial under the temperature conditions stated in the lot documentation, protected from light and moisture. Before opening, allow the vial to reach room temperature to limit condensation on the material. Minimise repeated freezing and thawing of laboratory stocks, retain the lot identifier in experimental records and wear standard laboratory protective equipment.

Questions about 5-Amino-1MQ

References

1. Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells. J Obstet Gynaecol 2021. PMID 33645410
2. Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. Sci Rep 2022. PMID 35013352

Identity data checked on 2026-09-24. Literature summaries describe published research models and are not specifications of any product lot.