BPC 157

BPC-157 is a synthetic 15-residue peptide whose sequence corresponds to part of a larger protein isolated from human gastric juice.

Identity

Sequence

H-GEPPPGKPADDAGLV-OH

Residues

15

Molecular formula

C₆₂H₉₈N₁₆O₂₂

Average molecular weight

1419.5 g/mol

Monoisotopic mass (calculated)

1418.7042 Da

CAS number

137525-51-0

PubChem CID

9941957

Strengths

5–10 mg

Other names

Body Protection Compound 157 · PL 14736 · Bepecin

Identity data from: PubChem CID 9941957

Research overview

BPC-157 is a pentadecapeptide with the sequence Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. It corresponds to part of a larger protein, called body protection compound, that was isolated from human gastric juice, and the literature describes the synthetic peptide as stable in gastric juice [1][2]. The name is also written BPC 157, and the peptide appears in some records under the development code PL 14736.

Most published work comes from rodent models, chiefly rats. Reviews summarise studies in transected tendon, ligament, muscle and bone injury models, in which the investigators report faster structural and functional recovery in animals given the peptide than in controls [1][2]. In a frequently cited study, rats with a transected Achilles tendon were examined alongside cultured tendon fibroblasts, and the authors describe increased outgrowth of these cells in vitro [3].

A second body of work concerns skin and other wound models, where investigators have linked the peptide to blood-vessel formation, nitric oxide signalling and growth-factor pathways, largely in studies in rats [2]. Reviewers point out that the evidence is still largely preclinical and call for further studies before broader conclusions are drawn [1].

Laboratory storage and handling

Keep the sealed vial refrigerated or frozen, dry and away from light, following the storage conditions on the documentation supplied with the lot. Allow the vial to reach room temperature before opening so that moisture does not condense on the powder. Avoid repeated freezing and thawing of laboratory stocks, note the lot number with each experiment and use standard laboratory protective equipment.

Questions about BPC-157

References

1. Gastric pentadecapeptide body protection compound BPC 157 and its role in accelerating musculoskeletal soft tissue healing. Cell Tissue Res 2019. PMID 30915550
2. Stable Gastric Pentadecapeptide BPC 157 and Wound Healing. Front Pharmacol 2021. PMID 34267654
3. Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. J Orthop Res 2003. PMID 14554208

Identity data checked on 2026-09-24. Literature summaries describe published research models and are not specifications of any product lot.