Chonluten

Chonluten is a synthetic Glu-Asp-Gly tripeptide described in THP-1 monocyte and macrophage signalling experiments.

Identity

Sequence

H-EDG-OH

Residues

3

Molecular formula

C₁₁H₁₇N₃O₈

Average molecular weight

319.27 g/mol

Monoisotopic mass (calculated)

319.1016 Da

CAS number

75007-24-8

PubChem CID

194641

Other names

EDG

The full cited paper explicitly identifies Chonluten as Glu-Asp-Gly; the database verifies free EDG. Direct literature is limited, so one paper is cited. The research is connected to the originating group. UniProt is inapplicable; SMILES and 2D coordinates were not transcribed.

Identity data from: PubChem CID 194641: properties, biologic line notation and synonyms · PubMed PMID 35408963: Chonluten sequence in the full paper Peptides section

Research overview

Chonluten is the tripeptide Glu-Asp-Gly, abbreviated EDG. In the full text of the cited study, investigators identify it as a synthetic peptide based on information from a tissue-derived counterpart. Its terminal glycine and two preceding acidic residues distinguish the sequence from other short peptides in the same paper. That investigation compared Chonluten with several defined peptides and a peptide complex, so their identities and individual observations should remain separate [1].

The experiments used the THP-1 monocytic cell line and cells differentiated toward a macrophage phenotype. They assessed proliferation-related kinase phosphorylation, including ERK1/2 and JNK, together with cytokine measurements under lipopolysaccharide stimulation. The paper reported lower TNF production in monocytes exposed to Chonluten in that experimental context [1]. It also examined cytokine patterns in differentiated cells and adhesion to activated endothelial-cell layers. Those assays connect intracellular signals with a cell-interaction readout, but the shared panel design does not mean that all peptides produced identical changes. A cell line, a differentiation condition and a particular inflammatory stimulus define the observation; they do not establish a specific molecular receptor for EDG or an organ-level response [1].

The cited biological literature is limited and mainly comes from one connected research group. These experiments describe particular cell or tissue systems. Their readouts do not establish a general mechanism across organs, and independent replication remains important when assessing the proposed molecular interactions [1].

Laboratory storage and handling

Follow the storage conditions stated in the documentation supplied with the lot. Keep the sealed vial cold, dry and protected from light. Let it reach room temperature before opening to reduce moisture condensation on the material. Avoid repeated freezing and thawing of laboratory stocks, record lot identifiers with experiments and wear standard laboratory protective equipment. Published biological observations do not establish storage stability for a particular lot.

Questions about Chonluten

References

1. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci 2022. PMID 35408963

Identity data checked on 2026-10-03. Literature summaries describe published research models and are not specifications of any product lot.