Sermorelin Acetate

Sermorelin is the amidated 29-residue amino-terminal fragment of growth hormone-releasing hormone, also called GRF (1-29) amide.

Identity

Sequence

H-YADAIFTNSYRKVLGQLSARKLLQDIMSR-NH2

Residues

29

Molecular formula

C₁₄₉H₂₄₆N₄₄O₄₂S

Average molecular weight

3357.9 g/mol

Monoisotopic mass (calculated)

3355.8187 Da

CAS number

86168-78-7

PubChem CID

16132413

Strengths

5–10 mg

Other names

GRF (1-29) amide · GHRH (1-29)NH2

Identity data from: PubChem CID 16132413

Research overview

Sermorelin is the amidated fragment comprising the first 29 residues of growth hormone-releasing hormone, also known as growth hormone-releasing factor. Its names GRF (1-29) amide and GHRH (1-29)NH2 describe the sequence range and the carboxyl-terminal amide. The peptide begins with tyrosine and ends with arginine, with a free amino terminus. Glycine occupies residue 15 in the structure given here [1].

The cited structure–activity study compared GRF receptor binding with activity in vitro. Its analogues included 29-residue amides in which alanine or sarcosine replaced glycine at residue 15. The study also examined fragments corresponding to cleavage by DPP-IV and trypsin-like enzymes. Receptor-binding affinity and growth hormone-releasing activity were the paired measurements used to examine these sequence changes. The analysis discussed amphiphilic alpha-helical interactions in relation to the residue-15 substitutions. The comparison included amidated hGRF(1-44) as a reference for the substituted 29-residue analogues [1].

The second reference reviews growth hormone-releasing peptides as a separate family of synthetic oligopeptides acting through a receptor distinct from the GHRH receptor. It includes comparisons involving GHRH (1-29)NH2 and GHRP-2, as well as experiments on GHRP-6 in female dwarf rats. In those rat experiments, in situ hybridization measured GHRH and somatostatin messenger RNA in hypothalamic regions, including the arcuate and periventricular nuclei [2].

Laboratory storage and handling

Store the sealed vial at the temperature specified in the lot documentation, protected from light and moisture. Allow the closed vial to reach room temperature before opening to limit condensation on the material. Avoid repeated freezing and thawing of laboratory stocks. Record the lot identifier and storage history with the experiment, and use standard laboratory protective equipment when handling the peptide.

Questions about Sermorelin

References

1. GRF analogs and fragments: correlation between receptor binding, activity and structure. Peptides 1991. PMID 1656403
2. Growth hormone-releasing peptides: clinical and basic aspects. Horm Res 1996. PMID 8950613

Identity data checked on 2026-09-24. Literature summaries describe published research models and are not specifications of any product lot.