LYSINE-PROLINE-VALINE

KPV is the tripeptide Lys-Pro-Val, corresponding to the C-terminal three residues of α-melanocyte-stimulating hormone.

Identity

Sequence

H-KPV-OH

Residues

3

Molecular formula

C₁₆H₃₀N₄O₄

Average molecular weight

342.43 g/mol

Monoisotopic mass (calculated)

342.2267 Da

CAS number

67727-97-3

PubChem CID

125672

Strengths

5–10 mg

Other names

Lys-Pro-Val · α-MSH (11-13)

Identity data from: PubChem CID 125672

Research overview

KPV consists of lysine, proline and valine, giving the sequence Lys-Pro-Val. It corresponds to the C-terminal tripeptide of α-melanocyte-stimulating hormone, commonly abbreviated α-MSH [2]. The review cited here distinguishes this short terminal sequence from the region required for binding to known melanocortin receptors. Although both the parent peptide and related short peptides appear in inflammation research, the review emphasizes that the exact signaling mechanism of KPV was unresolved [2].

The experimental paper examined cellular uptake as a specific mechanistic question. Investigators used intestinal epithelial cell lines Caco2-BBE and HT29-Cl.19A, along with Jurkat T cells, to examine the peptide transporter PepT1 [1]. Uptake measurements and signaling assays linked KPV transport to PepT1 and recorded lower activation of NF-kappaB and MAP kinase pathways in the studied cell systems. The same work examined mouse colitis models induced by DSS or TNBS, assessing tissue histology and cytokine gene expression [1]. The cell assays included an NF-kappaB luciferase reporter, Western blotting, real-time RT-PCR and ELISA. Uptake experiments used labelled KPV and competition with a labelled PepT1 substrate to examine transport kinetics [1]. Cells were examined with and without KPV in the presence of inflammatory cytokines. PepT1 was described as a transporter for dipeptides and tripeptides [1].

Laboratory storage and handling

Store the closed container cold, dry and protected from light under the conditions specified for the lot. Let it reach room temperature before opening to limit condensation. Avoid repeated freezing and thawing of laboratory stocks. Record storage history and lot identity alongside experiments, and use standard laboratory protective equipment when handling the material.

Questions about KPV

References

1. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology 2008. PMID 18061177
2. Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore. Adv Exp Med Biol 2010. PMID 21222263

Identity data checked on 2026-09-24. Literature summaries describe published research models and are not specifications of any product lot.